Advancing Cancer Research with UID Technology

Innovative Tools for Identification, Monitoring, and Automation in Preclinical Oncology

Preclinical cancer research relies on precision, reproducibility, and humane practices. From tumor tracking to treatment toxicity, the quality of data depends not only on experimental design, but also on how that data is collected, managed, and interpreted. Unified Information Devices (UID) supports cancer researchers across all stages of preclinical research with a suite of integrated technologies that streamline study workflows, reduce stress on animals, and provide reliable and continuous data. UID’s solutions — including microchip-based identification, temperature monitoring, home cage activity tracking, and automated data capture systems — are designed to enhance study integrity and accelerate discoveries in cancer biology and therapeutics.

In oncology studies, especially those using xenograft or orthotopic models, even minor data inconsistencies can compromise entire trials. UID’s RFID-based animal identification and monitoring systems ensure:

  • Unambiguous animal tracking across timepoints and procedures
  • Hands-free data capture integrated with electronic calipers and balances
  • Automated workflows that reduce transcription errors and operator bias

Impact: Every measurement is accurately tied to the right subject — strengthening reproducibility, reducing rework, and supporting GLP compliance.

Handling stress can significantly affect tumor growth, immune response, and behavior in rodents. UID reduces stress and supports refinement with:

  • Subcutaneous temperature transponders for non-invasive health monitoring
  • Home Cage Monitoring (HCM) systems for undisturbed activity and temperature tracking
  • Minimal handling protocols thanks to contactless RFID scans

Impact: Healthier, more stable animals generate higher-quality, more reliable data — and studies better align with IACUC and AAALAC standards.

Cancer progression and treatment response are dynamic processes. UID’s Home Cage Monitoring and RFID temperature systems allow for:

  • Continuous 24/7 data collection
  • Early detection of distress, fever, or behavioral changes
  • Rich, time-stamped datasets for correlating physiology, activity, and treatment cycles

Impact: Researchers can identify inflection points earlier, refine endpoints, and build deeper insights into drug efficacy and tolerability.

UID’s piSuite Oncology application consolidates tumor measurements, body weight, and animal ID into a single, automated platform. With seamless integration to RFID readers, electronic calipers, and balances, you get:

  • Efficient data collection across large cohorts
  • Standardized workflows across technicians and sites
  • Audit-ready reports for regulatory submissions

Impact: More data, fewer errors, and less time spent on manual entry or reconciliation — boosting throughput without sacrificing quality.

UID in Action: Supporting All Phases of Cancer Research

Research Phase UID Value
Tumor Implantation Confident animal tracking from Day 0
Treatment Evaluation Hands-free, consistent tumor & weight measurements
Toxicity Monitoring Continuous temperature & behavior tracking
Survival Studies Improved humane endpoint detection
Data Analysis & Reporting Integrated, standardized outputs for review and compliance

In oncology studies, accuracy, consistency, and animal well-being aren’t optional — they’re essential. UID provides an integrated toolkit that supports these priorities from engraftment to endpoint. With UID, cancer research teams can collect cleaner data, reduce animal stress, and confidently translate findings to the clinic.

Better data. Better decisions. Better science.

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UID Product Portfolio for Cancer Research Applications

  • Animal Identification and Tracking

    UID’s high-quality RFID microchips provide permanent, reliable animal identification. Combined with cost-effective, durable handheld and automated readers, UID supports fast, error-free ID verification. Systems are software-agnostic and compatible with any LIMS or electronic data platform, facilitating seamless integration into existing workflows.

  • Temperature Monitoring

    The UID Temperature Monitoring System uses implantable temperature transponders (±0.1°C accuracy) for stress-free, real-time monitoring. These dual-function RFID devices provide both animal ID and temperature data through a single, contactless scan.

  • Home Cage Monitoring

    The UID Mouse Matrix allows for continuous, group-housed animal monitoring using RFID to track activity, location, and temperature. Data is automatically collected day and night, eliminating the need for manual intervention and enabling detection of subtle changes in physiology and behavior.

  • piSuite Tumor Measurement Application

    UID’s piSuite Oncology software streamlines tumor measurement and weight tracking. It integrates with RFID readers, electronic calipers, and balances to automate data collection, reduce errors, and improve consistency. Ideal for xenograft, orthotopic, and PDX studies.

Featured Application: UID Technology in Toxicology Study of 2-DG and Ketogenic Diet

A preclinical study by Zielinski et al. (AACR-NCI-EORTC, 2023) investigated the safety and toxicological profile of combining a ketogenic diet (KD) with 2-deoxy-D-glucose (2-DG), a glycolysis inhibitor. While prior studies suggested synergy between KD and 2-DG in cancer therapy, this group observed a dose-dependent reduction in survival, highlighting critical safety concerns when combining metabolic interventions.

Featured Publications

  • Goldin, Kerry, et al. “Enhanced encephalitic tropism of bovine H5N1 compared to the Vietnam H5N1 isolate in mice.” bioRxiv (2024): 2024-11.
  • Rao, Deepashri, et al. “Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection.” (2024).
  • Lee, Hye-Lim, et al. “Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice.” Pharmacological Research 199 (2024): 107049.
  • Rao, Deepashri, et al. “CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice.” EBioMedicine 97 (2023).
  • Sriramula, Srinivas, et al. “Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection.” Cells 12.16 (2023): 2107.
  • Sriram, Srinivas, et al. “Long COVID in K18-hACE2 mice causes persistent brain inflammation and cognitive impairment.” (2022).
  • Leventhal, Shanna S., et al. “Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge.” EBioMedicine 82 (2022).
  • Wang, Tiecheng, et al. “Proteomic and metabolomic characterization of SARS-CoV-2-infected cynomolgus macaque at early stage.” Frontiers in Immunology 13 (2022): 954121.
  • Smeyne, Richard J., et al. “COVID‐19 infection enhances susceptibility to oxidative stress–induced parkinsonism.” Movement Disorders 37.7 (2022): 1394-1404.
  • Carossino, Mariano, et al. “Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression.” Biorxiv (2021): 2021-01.
  • Subramaniam, Saravanan, et al. “Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice.” Biorxiv (2021): 2021-08.
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